PPHNet Publications

Kinsella JP, Steinhorn RH, Mullen MP, et al. “The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension” J Pediatrics, April 2018. Full text online at http://www.jpeds.com/article/S0022-3476(18)30287-7/fulltext

Krishnan U, Feinstein JA, Adatia I, et al. “Evaluation and Management of Pulmonary Hypertension in Children with Bronchoplumonary Dysplasia.” J Pediatrics. Volume 188, 24-34.  Full text online at http://www.jpeds.com/article/S0022-3476(17)30650-9/abstract​

Abman SH, Kinsella JP, Rosenzweig EB, et al. “Implications of the U.S. Food and Drug Administration Warning against the Use of Sildenafil for the Treatment of Pediatric Pulmonary Hypertension”, American Journal of Respiratory and Critical Care Medicine, Vol. 187, No. 6 (2013), pp. 572-575. http://www.atsjournals.org/doi/full/10.1164/rccm.201210-1928PP#.VS1ddBf7Kr8

Abman SH, Hansmann G, Archer SL, et al. “Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society.” Circulation 2015; 132(21): 2037-2099. http://www.ncbi.nlm.nih.gov/pubmed/26534956

Kinsella JP, Steinhorn RH, Krishnan US, et al. Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension J Pediatr 2016. 170:312-314. http://www.ncbi.nlm.nih.gov/pubmed?term=%28%28Kinsella%20J[Author]%29%20AND%20recommendations%20for%20the%20use%20of%20inhaled[Title]%29%20AND%20Steinhorn%20RH[Author]

PPHNet Research

Investigation of Actigraphy, an Exercise Measurement Device, as a Novel, Well-defined, Reliable, Feasible, Easy to Use, and Non-Invasive Study Endpoint to Facilitate Pediatric Pulmonary Arterial Hypertension Trials and Drug Development. Principal investigator: Dunbar Ivy  https://clinicaltrials.gov/ct2/show/NCT02909608

Pediatric Pulmonary Hypertension Network (PPHNet) Biorepository Program. Sponsor: Cardiovascular Medical Research Network Principal investigators: Eric D. Austin, M.D., Allen Everett, M.D.

Data Fusion: A Sustainable, Scalable, Open Source Registry Advancing PVD Research. National Heart, Lung, and Blood Institute (NHLBI) Project #1U01HL121518-01. Principal Investigators: Abman SH, Mandl KD.  https://clinicaltrials.gov/ct2/show/NCT02249923?term=pediatric+pulmonary+hypertension&rank=2

Relevant Research and Publications

Ivy D, Abman SH, Barst RJ, et al. “Pediatric Pulmonary Hypertension.” J Am Coll Cardiol. 2013;62(25_S):. doi:10.1016/j.jacc.2013.10.028.Full text online at http://content.onlinejacc.org/article.aspx?articleID=1790598 http://www.ncbi.nlm.nih.gov/pubmed

Progress in Pediatric Cardiology Volume 27, Issues 1–2, Pages 1-66 (December 2009) Pulmonary Hypertension. http://www.sciencedirect.com/science/journal/10589813/27/1

FDA Drug Safety Communication: Proglycem (diazoxide). Reports of Pulmonary Hypertension in Infants and Newborns

The U.S. Food and Drug Administration (FDA) warning on use of sildenafil in cases of pediatric pulmonary hypertension. http://www.fda.gov/Drugs/DrugSafety/ucm317123.htm